Precision dosing of polymyxin B based on XGBoost prediction of AUC


Scenario 1: Predict AUC based on time and concentration






Predicted AUCss, 24h:
Dose recommendation based on AUCss, 24h 50-100 mg·h/L:

Scenario 2: Predict AUC based on peak and trough concentrations






Predicted AUCss, 24h:
Dose recommendation based on AUCss, 24h 50-100 mg·h/L: